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SSH2 siRNA

Development stage: Preclinical
Lead developer: University of Birmingham
Modality: Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration: Intralesional

Overview

SSH2 siRNA is a small interfering RNA designed to silence the expression of the Slingshot2 (SSH2) serine phosphatase. SSH2 is a member of the Slingshot family involved in actin reorganization. Research indicates that knockdown of SSH2 specifically induces apoptosis (via caspase 3/7 activation) and G1 cell cycle arrest in human carcinoma cell lines lacking the Birt-Hogg-Dubé (BHD) tumor suppressor gene (folliculin/FLCN). This synthetic lethal relationship suggests that SSH2 inhibition could be a targeted therapeutic strategy for BHD-associated renal cell carcinoma and thyroid carcinoma.

Other names: slingshot2 siRNAslingshot-2 siRNAslingshot 2 siRNASSH2-targeting siRNASSH-2-targeting siRNASSH 2-targeting siRNA

Targets

SSH2 (Slingshot phosphatase 2)Innate immune RNA sensors

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