ST32da

ST32da is a synthetic small molecule originally isolated from Salvia miltiorrhiza and identified as a potent inducer of activating transcription factor 3 (ATF3). It was discovered through an ATF3-specific promoter screening platform. Mechanistically, ST32da promotes the expression of ATF3, which in turn downregulates adipokine and inflammatory genes, suppresses lipogenesis, and induces the browning of white adipocytes by inhibiting the carbohydrate-responsive element-binding protein–stearoyl-CoA desaturase-1 (ChREBP-SCD-1) axis. In preclinical studies with mice on a high-fat diet, oral administration of ST32da increased white adipose tissue browning, reduced lipogenesis, improved insulin sensitivity, and showed anti-obesity efficacy comparable to orlistat. These findings suggest that ST32da may be a promising therapeutic candidate for treating diet-induced obesity and related metabolic disorders[1][2][4][5].