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standard group-University of Sao Paulo General Hospital-postoperative pain

Development stage
Unknown
Lead developer
University of Sao Paulo General Hospital
Modality
Small Molecules
Administration
Perineural, Intravenous
01

Overview

The "Standard group" refers to the control arm of a clinical trial (NCT02683330) conducted by the University of Sao Paulo General Hospital, investigating the efficacy of preemptive analgesia for postoperative pain management in patients undergoing arthroscopic rotator cuff repair. This protocol involves a two-stage process: an initial ultrasound examination of the brachial plexus performed 48 hours prior to surgery (without drug administration), followed by a standard ultrasound-guided brachial plexus blockade and sedation on the day of the operation. The blockade typically utilizes local anesthetics to provide regional anesthesia and analgesia. The study compares this standard-of-care approach against a preemptive group that receives an active blockade 48 hours earlier, aiming to evaluate the impact on central and peripheral nociceptive sensitization and subsequent postoperative opioid requirements.

Other names
Standard groupStandard brachial plexus blockade protocol
02

Targets

NaV (Voltage-gated sodium channels)

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