standard platinum-based chemotherapy + bevacizumab

A combination of **standard platinum-based chemotherapy** (most commonly including cisplatin, carboplatin, or oxaliplatin, sometimes with agents such as paclitaxel, docetaxel, or gemcitabine) with **bevacizumab**, a humanized monoclonal antibody targeting vascular endothelial growth factor A. This regimen is employed in the treatment of various cancers, most notably non-squamous non-small cell lung cancer, ovarian cancer, and metastatic colorectal cancer. Platinum agents cause DNA crosslinking, inhibiting DNA synthesis and repair, leading to cell death, while bevacizumab blocks angiogenesis by inhibiting VEGF-A, thus depriving tumors of blood supply and nutrients[1][2][3][4][5][6][8].

Brand names

AvastinMvasiZirabevAlymsysVegzelma

Other names

standard platinum-based chemotherapy and bevacizumabplatinum doublet plus bevacizumab