Standard protocol-Boston Urogynecology Associates-overactive bladder

Standard protocol-Boston Urogynecology Associates-overactive bladder refers to a specific analgesic regimen used as a control arm in clinical research conducted by Boston Urogynecology Associates. The protocol is designed to manage pain during the intravesical administration of onabotulinumtoxinA (Botox) in women with refractory overactive bladder. It consists of a pre-procedure bladder instillation of 100 mL of a solution containing 50 mL of 1% lidocaine and 50 mL of 0.9% saline, administered 20 minutes prior to the therapeutic injections. Lidocaine, the active pharmaceutical ingredient, is a small molecule local anesthetic that functions by blocking voltage-gated sodium channels in the neuronal cell membrane. This blockade prevents the initiation and conduction of nerve impulses, thereby providing localized anesthesia to the bladder mucosa and reducing procedural discomfort during cystoscopic intradetrusor injections.

Other names

Standard lidocaine protocolLidocaine 0.5% intravesical solution