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Standard Regimen-University of California, San Francisco-cataract
- Development stage
- Unknown
- Lead developer
- University of California, San Francisco
- Modality
- Small Molecules
- Administration
- Ophthalmic, Intracameral
01
Overview
The Standard Regimen-University of California, San Francisco-cataract refers to the conventional postoperative eye drop protocol used as a control arm in clinical trials (notably NCT05157113) at Zuckerberg San Francisco General Hospital. This multi-drug regimen is designed to prevent infection and inflammation following cataract surgery. It consists of an intraoperative intracameral injection of the antibiotic cefuroxime, followed by a self-administered postoperative course of topical drops: Neomycin/Polymyxin B (antibiotic), Ketorolac (non-steroidal anti-inflammatory drug), and Prednisolone acetate (corticosteroid). The regimen is being evaluated against "dropless" alternatives due to the high burden of adherence associated with multiple daily administrations in vulnerable populations.
- Other names
- Standard RegimenStandard drop regimenTraditional standard drop regimen
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)Bacterial RibosomePTGS2 (Prostaglandin-Endoperoxide Synthase 2)PBP (Penicillin-binding protein family)GR (Glucocorticoid receptor)
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