Standardized Cat Allergen Extract + Standardized Dust Mite Allergen-Massachusetts General Hospital

Standardized Cat Allergen Extract + Standardized Dust Mite Allergen-Massachusetts General Hospital is a combination of biological allergen extracts used as a bronchoprovocation challenge agent in clinical research. Developed for use in physiological studies at Massachusetts General Hospital, this combination is administered via inhalation to patients with mild allergic asthma to induce a controlled asthmatic response. The mechanism involves the cross-linking of allergen-specific IgE antibodies bound to high-affinity IgE receptors (FcεRI) on the surface of mast cells and basophils in the pulmonary mucosa. This activation triggers the release of inflammatory mediators such as histamine and leukotrienes, leading to airway smooth muscle contraction (bronchoconstriction). This controlled induction of an asthma attack allows researchers to evaluate pulmonary blood flow redistribution and gas exchange impairment using advanced imaging techniques like Positron Emission Tomography (PET) and Computed Tomography (CT).

Other names

Standardized Cat Allergen Extract and Standardized Dust Mite Allergen