Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
staphylea bumalda extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Staphylea bumalda extract (SBE) is a botanical extract derived from the tender leaves and buds of *Staphylea bumalda*, an edible shrub native to temperate regions of Asia. The extract is rich in bioactive flavonoids, specifically hyperoside, kaempferol-3-O-rutinoside, isorhoifolin, and rutin. In preclinical research, SBE has demonstrated significant therapeutic potential for the treatment of ulcerative colitis (UC). Its mechanism involves the reduction of pro-inflammatory cytokines, including interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), as well as the inhibition of oxidative stress markers such as myeloperoxidase (MPO) and nitric oxide (NO). Furthermore, SBE appears to modulate the gut microbiota by increasing the abundance of beneficial bacteria like *Lactobacillus*, thereby maintaining intestinal homeostasis and reducing mucosal injury.
- Other names
- Staphylea bumalda tender leaves and buds extractS. bumalda extract
02
Targets
IL-6 (Interleukin 6)MPO (Myeloperoxidase)TNFA (Tumor necrosis factor alpha (soluble))NOS2 (Nitric Oxide Synthase 2)IL1B (Interleukin-1 beta)
Beyond the preview
Go deeper on staphylea bumalda extract.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on staphylea bumalda extract.