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Staphylococcus epidermidis bacteriophage
- Development stage
- Unknown
- Lead developer
- Cytophage Technologies
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Intravenous, Intraarticular
01
Overview
A lytic mono-bacteriophage preparation developed by the Ottawa Hospital Research Institute in collaboration with Cytophage Technologies. This phage therapy is specifically designed to target and destroy methicillin-resistant *Staphylococcus epidermidis* (MRSE). It has been evaluated in a single-patient clinical trial in Canada for a life-threatening, chronic periprosthetic joint infection (PJI) that was resistant to multiple antibiotics. The treatment involves both intravenous and intra-articular administration and is used as an adjunct to standard antibiotic therapy. The bacteriophage works by infecting and killing the target bacteria, offering a therapeutic alternative for difficult-to-treat biofilm-associated infections.
- Other names
- Phage-Ottawa Hospital Research Institute-periprosthetic joint infection
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