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star anise
- Development stage
- Phase 4
- Modality
- Small Molecules
- Administration
- Oral, Inhalation, Topical, Intraperitoneal
01
Overview
Star anise (Illicium verum) is a spice derived from the fruit of the Chinese evergreen tree Illicium verum. It is widely used in traditional Chinese medicine and culinary applications. It contains powerful bioactive compounds, including trans-anethole, shikimic acid, flavonoids, and sesquiterpenes, which contribute to its diverse pharmacological properties. These properties include antiviral, antibacterial, antifungal, antioxidant, anti-inflammatory, and insecticidal effects. It is also a source of shikimic acid, a precursor for the antiviral drug oseltamivir (Tamiflu).
- Other names
- Illicium verumIllicium verum Hook. f.aniseed starsbadianChinese aniseba jiao hui xiang
02
Targets
Cyp (Cyclophilin family)AKT (RAC-alpha serine/threonine-protein kinase)Actin filament proteinsSucrase-IsomaltaseACE (Angiotensin Converting Enzyme)CES1 (Liver carboxylesterase 1)NeuraminidaseCOX7C (Cytochrome c oxidase subunit 7C, mitochondrial)GST (Glutathione S-transferase alpha 3)GPX4 (Glutathione peroxidase 4)IL1B (Interleukin-1 beta)GehA (Triacylglycerol lipase GehA)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)Misfolded SOD1TLR4 (Toll-like receptor 4)TNFA (Tumor necrosis factor alpha (soluble))
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