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Steamed American ginseng berry extract (S-AGE) is a heat-processed botanical extract derived from the berries of *Panax quinquefolius*. The steaming process significantly alters the ginsenoside composition, notably increasing the concentration of ginsenoside Rg3, which is associated with enhanced anticancer properties. Preclinical research indicates that S-AGE exerts potent antiproliferative effects on colorectal cancer cells by inducing G1-phase cell cycle arrest and promoting apoptosis. In vivo studies using xenograft models have demonstrated that S-AGE can significantly inhibit tumor growth, highlighting its potential as a therapeutic or chemopreventive agent for colorectal cancer.
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