steamed american ginseng extract

Steamed American ginseng extract is a thermally processed derivative of *Panax quinquefolius* L. roots, typically prepared by steaming at 120°C for 2 hours. This processing method significantly increases the concentration of rare ginsenosides, most notably ginsenoside Rg3, which are absent or present in minimal amounts in raw ginseng. The extract has demonstrated potent anti-cancer and antiproliferative activities, particularly against human colorectal cancer cells such as the HCT-116 line. Its mechanism of action involves the modulation of multiple gene expression pathways, with the Ephrin receptor pathway identified as a primary target. Research indicates that the extract regulates the expression of several genes, including the up-regulation of AKAPA8L, PMPCB, and PDE5A, and the down-regulation of PITPNA, DUS2L, and RIC8A, which collectively contribute to its tumor-inhibitory effects.

Other names

steamed Panax quinquefolius extract