Drug intelligence / Profile preview

Steamed ginger ethanolic extract

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Steamed ginger ethanolic extract is a concentrated preparation derived from the rhizome of Zingiber officinale (ginger) that has undergone a steaming process followed by extraction with ethanol. This process increases the content of 6-shogaol, a bioactive compound believed to enhance the potency of the extract compared to non-steamed or aqueous extracts[1][5][6]. Steamed ginger ethanolic extract has demonstrated anti-obesity effects in clinical trials, significantly reducing body weight, body mass index, and body fat in obese individuals without notable side effects[1]. Mechanistically, it is thought to exert its effects by inhibiting hepatic lipid accumulation through suppression of lipogenic transcription factors such as SREBP1c and by exhibiting anti-inflammatory activity via inhibition of nitric oxide (NO) and prostaglandin E2 (PGE2) production[1][5][8]. Additional studies have shown potential benefits for pain relief and organ protection due to its anti-inflammatory properties[3][8].

Other names
steamed ginger extractSGEGGE03GGE-03GGE 03AZOE
02

Targets

NOS1 (nNOS)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)SREBP-1 / SREBF1 (SREBP-1)

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