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STI-002

Development stage: Preclinical
Lead developer: Stimunity
Modality: Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration: Systemic

Overview

STI-002 is a second-generation immuno-oncology drug candidate developed by Stimunity S.A. It is based on cGAMP-VLP technology, which involves encapsulating the endogenous STING activator cGAMP within Virus-Like Particles (VLPs). This approach aims to activate the innate immune system, enhance T-cell responses against tumor cells, and stimulate dendritic cell activation, with a preferential targeting of dendritic cells. The drug is designed for systemic administration and has shown potential to synergize with immune checkpoint therapies in preclinical studies for cancer treatment.

Targets

STING (Stimulator of interferon genes protein)

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