Drug intelligence / Profile preview

stimotimagene copolymerplasmid

Development stage
Phase 1
Lead developer
Gene Surgery
Modality
Gene Therapies, Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Intratumoral
01

Overview

Stimotimagene copolymerplasmid is an investigational anti-tumor gene therapy developed by Gene Surgery LLC for the treatment of solid tumors, including advanced malignant solid neoplasms, anus neoplasms, and breast cancer. It is currently in Phase 1 clinical trials. The therapy utilizes a non-viral gene transfer approach to deliver therapeutic genetic material directly into tumor cells, aiming to stimulate anti-tumor immune responses and inhibit tumor growth. The specific mechanism involves gene transference via a plasmid-copolymer complex; however, the precise genetic payload or target has not been publicly disclosed[1][2][3].

02

Targets

CD28 (Cluster of Differentiation 28)Plasmid DNA phosphate backbone

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