STING-NP

STING-NP is a nanoparticle-based immunotherapy designed to activate the Stimulator of Interferon Genes (STING) pathway. It consists of polymer vesicles (polymersomes) engineered for the efficient cytosolic delivery of 2’3’ cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), an endogenous cyclic dinucleotide (CDN) ligand. By overcoming the delivery barriers of free CDNs—such as poor membrane permeability and rapid enzymatic degradation—STING-NP enhances the activation of innate immunity within the tumor microenvironment. Preclinical studies, particularly in murine melanoma models, have shown that intratumoral administration of STING-NP increases tumor immunogenicity and works synergistically with immune checkpoint inhibitors (anti-PD-1/CTLA-4) to promote systemic anti-tumor responses and overcome immune escape mechanisms.

Other names

STING-activating nanoparticles