STING siRNA

STING siRNA (small interfering RNA targeting Stimulator of Interferon Genes) is a class of gene-silencing therapeutics designed to downregulate the expression of the STING protein (encoded by the STING1/TMEM173 gene). STING is a critical adaptor protein in the cyclic GMP-AMP synthase (cGAS)-STING pathway, which senses cytosolic double-stranded DNA (dsDNA) to trigger innate immune responses, primarily through the induction of type I interferons and pro-inflammatory cytokines. While activation of the STING pathway is beneficial for antiviral defense and antitumor immunity, aberrant or chronic STING activation is implicated in various inflammatory, autoimmune, and degenerative diseases, including doxorubicin-induced cardiotoxicity, acute lung injury, and intervertebral disc degeneration. Consequently, STING siRNA is being investigated in preclinical research as a targeted therapeutic strategy to mitigate pathological inflammation and tissue damage by silencing STING expression.

Other names

STING small interfering RNAsi-STINGsiSTING