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STMC-105
- Development stage
- Preclinical
- Lead developer
- Siolta Therapeutics
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Intravaginal, Oral
01
Overview
**STMC-105** is a preclinical, multi-strain vaginal live biotherapeutic product being developed by Siolta Therapeutics to prevent recurrent bacterial vaginosis. It is a defined vaginal bacterial consortium designed to restore and durably maintain protective Lactobacillus-dominant vaginal microbiota, thereby improving resilience against microbiota disruption, opportunistic-pathogen colonization, and bacterial-vaginosis recurrence. The planned product includes protective *Lactobacillus crispatus*, *Lactobacillus gasseri*, and *Lactobacillus jensenii* species and is being developed as a mucoadhesive extended-release vaginal tablet. ([sioltatherapeutics.com](https://www.sioltatherapeutics.com/pipeline/))
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