STO-609

STO-609 is a potent and selective small molecule inhibitor of Calcium/Calmodulin-dependent Protein Kinase Kinase (CaMKK), targeting both the alpha (CaMKK1) and beta (CaMKK2) isoforms. It acts as an ATP-competitive inhibitor, effectively blocking the CaMKK-mediated phosphorylation of downstream targets, most notably AMP-activated protein kinase (AMPK) and Calcium/Calmodulin-dependent protein kinases I and IV (CaMKI and CaMKIV). STO-609 is widely utilized as a pharmacological tool in research to dissect the roles of CaMKK signaling in diverse biological processes, including glucose metabolism, autophagy, and cancer cell survival under stress. In oncology research, it has been used to demonstrate that the CaMKK-AMPK pathway is a critical survival mechanism for ovarian cancer cells in spheroid form, which are often subjected to metabolic and bioenergetic stress.

Other names

7-Oxo-7H-benz[de]anthracene-3-carboxylic acid