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Drug intelligence / Profile preview
stomatin-like protein 2
- Development stage
- Preclinical
- Lead developer
- Eurac Research
- Modality
- Gene Therapies
- Administration
- Intracerebral
01
Overview
Stomatin-like protein 2 (SLP-2), also known as STOML2, is a member of the stomatin family located in the inner mitochondrial membrane. It acts as a mitochondrial scaffold protein that regulates mitochondrial function, integrity, and bioenergetics by organizing cardiolipin-enriched membrane domains and stabilizing mitochondrial respiratory chain complexes. In therapeutic development for Parkinson's disease, SLP-2 is being investigated as a gene therapy target; increasing its expression via viral vectors (such as AAV) has been shown to rescue mitochondrial dysfunction, reduce oxidative stress, and prevent the loss of dopaminergic neurons in models of alpha-synuclein neuropathology.
- Other names
- STOML2STOML-2STOML 2Stomatin-like protein 2
02
Targets
PARL (Presenilin-associated rhomboid-like protein, mitochondrial)PRKN (E3 ubiquitin-protein ligase parkin)PHB1 (Prohibitin 1)PHB2 (Prohibitin 2)SLP-2 (Stomatin-like protein 2, mitochondrial)YME1L1 (YME1-like 1 ATPase)
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