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STRA6-targeted shRNA
- Development stage
- Preclinical
- Lead developer
- Asan Medical Center
- Modality
- Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
STRA6-targeted shRNA is a short hairpin RNA (shRNA) therapeutic designed to silence the expression of stimulated by retinoic acid 6 (STRA6), a cell-surface receptor for retinol-binding protein. Developed by researchers at the Asan Medical Center and the University of Ulsan College of Medicine, this RNA interference therapy specifically targets STRA6, which is highly upregulated in tumor-supportive cancer-associated fibroblasts (CAFs) within the pancreatic ductal adenocarcinoma (PDAC) microenvironment. By knocking down STRA6 expression, the therapy inhibits CAF-mediated tumor progression, overcomes stromal-driven chemoresistance, and synergizes with gemcitabine to achieve durable tumor regression and prevent rapid recurrence.
- Other names
- STRA6-KDSTRA-6-KDSTRA 6-KDSTRA6-targeted short hairpin RNASTRA-6-targeted short hairpin RNASTRA 6-targeted short hairpin RNA
02
Targets
Innate immune RNA sensorsSTRA6 (Stimulated by retinoic acid gene 6 protein)
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