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Strengthening Spleen Smoothing Liver Granules
- Development stage
- Unknown
- Lead developer
- Shuguang Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Strengthening Spleen Smoothing Liver Granules is a traditional Chinese medicine (TCM) herbal formula designed to address patterns of spleen deficiency and liver Qi stagnation. The formulation is based on the TCM theory of “One Qi Circulation,” originating from Qing Dynasty practices[1][7]. It typically contains multiple herbs that work synergistically to tonify (strengthen) the spleen, harmonize the liver, regulate Qi flow, and support digestive and metabolic health. The mechanism of action involves modulating intestinal flora, improving glucolipid metabolism, reducing inflammation, and restoring balance between organ systems—especially in conditions like non-alcoholic fatty liver disease (NAFLD)[7]. Clinical studies have shown its efficacy in improving symptoms related to NAFLD by regulating gut microbiota composition[7]. The exact herbal composition may vary by manufacturer but often includes classic spleen-tonifying herbs such as Atractylodes macrocephala (Bai Zhu), Astragalus membranaceus (Huang Qi), Codonopsis pilosula (Dang Shen), Angelica sinensis (Dang Gui), among others[2][9].
- Brand names
- Strengthening Spleen Smoothing Liver Granules
- Other names
- Spleen-strengthening and liver-draining formulaSLFJianpi Shugan Granules
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)
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