streptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate antigen

Streptococcus pneumoniae type 18C capsular polysaccharide diphtheria CRM197 protein conjugate antigen is a sterile vaccine component that contains saccharides of the capsular antigens of *Streptococcus pneumoniae* serotype 18C individually conjugated to the CRM197 protein, a nontoxic variant of diphtheria toxin isolated from cultures of *Corynebacterium diphtheriae* strain C7 (β197). This glycoconjugate is used as an active ingredient in pneumococcal conjugate vaccines such as Prevnar (PCV7 and later formulations), which are designed to protect against invasive pneumococcal disease caused by specific serotypes including type 18C[1][2][4]. The mechanism involves stimulating the immune system to produce antibodies against the bacterial capsule, thereby conferring protection mainly through opsonophagocytic killing[5]. The vaccine is indicated for prevention of pneumococcal disease in infants and young children.

Brand names

Prevnar

Other names

Streptococcus pneumoniae serotype 18C capsular antigen diphtheria CRM197 protein conjugate vaccineStreptococcus pneumoniae type 18c capsular polysaccharide diphtheria crm197 protein conjugate vaccine