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streptococcus thermophilus + lactobacillus delbrueckii subsp. bulgaricus
- Development stage
- Unknown
- Lead developer
- Danone
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Streptococcus thermophilus and Lactobacillus delbrueckii subsp. bulgaricus are lactic acid bacteria traditionally used as starter cultures for yogurt production. As a probiotic combination, they exhibit a proto-cooperative relationship where metabolic exchanges, such as nitrogen, purine, and iron metabolism, enhance their growth and functional properties. Therapeutically, this combination has been investigated as an adjunct to triple therapy for Helicobacter pylori eradication, where it helps improve eradication rates and reduce antibiotic-associated side effects. It also demonstrates protective effects on the intestinal barrier by ameliorating dysfunction caused by inflammatory cytokines and suppressing the internalization of nanoplastics in intestinal epithelial cells.
- Other names
- S. thermophilus + L. bulgaricusLactobacillus bulgaricus + Streptococcus thermophilusyogurt cultures
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