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streptococcus thermophilus TCI633
- Development stage
- Unknown
- Lead developer
- TCI Gene
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Streptococcus thermophilus TCI633 is a probiotic bacterial strain originally isolated from human breast milk and developed by TCI Co., Ltd. The strain is characterized by its ability to colonize the gastrointestinal tract and endogenously produce hyaluronic acid (HA). This mechanism is intended to provide systemic benefits, particularly in the management of musculoskeletal conditions. Clinical and preclinical studies have investigated TCI633 for the treatment of knee osteoarthritis (KOA), where it has demonstrated potential in reducing synovial tissue inflammation, protecting cartilage, and improving joint function as measured by WOMAC scores and biomarkers like sCTX-II and sCRP. Beyond joint health, the strain is explored for its anti-aging properties and potential to improve skin hydration and collagen synthesis.
- Other names
- Streptococcus thermophilus TCI633DSM 28121DSM28121DSM-28121BCRC 910636BCRC910636BCRC-910636
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