stresscopin

Stresscopin is a synthetic peptide analogue of the endogenous human urocortin III/stresscopin, a member of the corticotropin-releasing factor (CRF) peptide family and a highly selective agonist of the corticotropin-releasing factor type 2 receptor (CRFR2/CRHR2). It is a 2-amino-acid C‑terminal extension of urocortin III that maintains specific, high-affinity binding to CRFR2, leading to vasodilation, positive inotropic effects, suppression of food intake, delayed gastric emptying, and modulation of cardiac output and systemic vascular resistance.[1][12][14] Pharmacologically, intravenous human stresscopin acetate (JNJ-39588146) has shown dose-dependent increases in cardiac index and reductions in systemic vascular resistance without significant changes in heart rate or systolic blood pressure in patients with heart failure with reduced ejection fraction, supporting its development as an acute heart failure therapy.[2][5][10]

Other names

human stresscopinurocortin IIIUcn IIIstresscopin (human)SCP