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STRO-501
- Development stage
- Unknown
- Lead developer
- Stromacare
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
STRO-501 is an antibody-drug conjugate (ADC) targeting CD74, a protein highly expressed in B-cell malignancies. Developed by Sutro Biopharma using their proprietary XpressCF cell-free protein synthesis platform, the drug consists of a humanized anti-CD74 IgG1 antibody site-specifically conjugated to a maytansinoid payload via a non-cleavable linker. CD74 is rapidly internalized upon antibody binding, making it an ideal target for delivering cytotoxic agents directly into malignant cells. STRO-501 is primarily being investigated for the treatment of relapsed or refractory multiple myeloma and non-Hodgkin lymphoma.
02
Targets
CD74 (Major histocompatibility complex class II invariant chain)
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