strongylophorine-26

**Strongylophorine-26** is a meroditerpenoid natural product isolated from the marine sponge Petrosia corticata. It is characterized as a member of the diterpenoids, meroterpenoids, gamma-lactones, enol ethers, tertiary alcohols, and p-quinones. The compound has demonstrated antineoplastic effects, specifically inhibiting cancer cell invasion in vitro. Its architecture and configuration were confirmed by single-crystal X-ray diffraction and synthetic analog studies. This natural product is noted for its ability to suppress tumor cell migration and invasion, with the lactone moiety in its A ring being critical for biological activity. The first total synthesis and structure–activity relationship studies have been reported, but no clinical uses or pharmaceutical development are known.

Other names

strongylophorine-26strongylophorine26strongylophorine 26CHEBI:66527CHEMBL389231CHEMBL-389231CHEMBL 3892312-[[(1S,2S,5S,6S,7R,10R,11S)-5-hydroxy-5,7,11-trimethyl-12-oxo-13-oxatetracyclo[9.3.3.01,10.02,7]heptadecan-6-yl]methyl]-6-methoxycyclohexa-2,5-diene-1,4-dione2-{[(13alpha,14beta)-13-hydroxy-8,13-dimethyl-15-oxo-15,17-epoxypodocarpan-14-yl]methyl}-6-methoxycyclohexa-2,5-diene-1,4-dione