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strontium apatite
- Development stage
- Preclinical
- Lead developer
- Universidade de São Paulo
- Modality
- DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Nanoparticles → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems, Device-based Delivery → Drug Delivery Systems
- Administration
- Implant, Topical
01
Overview
Strontium apatite is a research-stage, strontium-substituted calcium phosphate (apatite) biomaterial developed as a bone substitute, filler, cement, or implant coating. It is designed to provide sustained local release of strontium ions directly to bone tissue as an alternative to systemic strontium therapies. Strontium ions released from the apatite lattice promote bone formation by stimulating osteoblast activity and inhibit bone resorption by suppressing osteoclast activity. Strontium apatite is investigated for potential applications in osteoporosis, bone defects, bone-graft or implant fixation, and alveolar bone resorption.
- Other names
- strontium hydroxyapatitestrontium-containing apatitestrontium-substituted calcium phosphatestrontium-substituted hydroxyapatite
02
Targets
CaSR (Extracellular calcium-sensing receptor)
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