Drug intelligence / Profile preview

strychnos nux-vomica

Development stage
Unknown
Lead developer
Medical University of Vienna
Administration
Sublingual
01

Overview

Strychnos nux-vomica, specifically in the homeopathic preparation Nux vomica C200, is a highly diluted plant extract derived from the seeds of the Strychnos nux-vomica tree. It is being investigated by the Medical University of Vienna in a Phase 4 clinical trial for the prophylaxis of postoperative atrial fibrillation (POAF) in adult patients undergoing cardiac surgery, such as aortocoronary bypass or heart valve surgery with cardiopulmonary bypass. Administered sublingually as globules, the preparation is evaluated for its potential to prevent arrhythmias and its effects on electrolyte balance. As a homeopathic remedy, it lacks a conventional pharmacological active ingredient or a defined molecular target, operating instead under the principles of potentization and dilution.

Other names
Nux vomicaPoison nutQuaker buttons
02

Targets

Nicotinic Acetylcholine ReceptorGABAA (Gamma-aminobutyric acid receptor)GLRA1 (Glycine receptor subunit Alpha-1)

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