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strychnos total alkaloids vesicle gel
- Development stage
- Unknown
- Lead developer
- Beijing Yingkerei Pharmaceutical Technology
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Strychnos Total Alkaloids Vesicle Gel is a topical traditional Chinese medicine (TCM) candidate developed by Beijing Yingkerei Pharmaceutical Technology for the treatment of pain and inflammation. The formulation utilizes a vesicle-based delivery system, such as liposomes or ethosomes, to encapsulate the total alkaloids extracted from *Strychnos nux-vomica*, which primarily include strychnine and brucine. This advanced delivery approach is designed to enhance transdermal penetration and provide localized therapeutic effects while significantly reducing the systemic toxicity typically associated with the oral administration of *Strychnos* alkaloids. Mechanistically, these alkaloids act as potent analgesics, with strychnine serving as a competitive antagonist of the inhibitory glycine receptor (GlyR) in the central nervous system and peripheral tissues, thereby modulating pain signaling pathways.
- Other names
- 马钱子总碱囊泡凝胶Strychnos Total Alkaloids Vesicle Gel
02
Targets
Glycine receptor
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