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Stupp protocol
- Development stage
- Unknown
- Lead developer
- European Organisation for the Research and Treatment of Cancer
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
The Stupp protocol is a standard-of-care treatment regimen for newly diagnosed glioblastoma (GBM). Developed in 2005 by Roger Stupp and colleagues in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) and the National Cancer Institute of Canada (NCIC) Clinical Trials Group, the protocol consists of maximal safe surgical resection of the tumor, followed by concurrent radiotherapy (60 Gy delivered in 30 daily fractions over 6 weeks) combined with daily oral chemotherapy using temozolomide (TMZ), and then adjuvant temozolomide chemotherapy for six 28-day cycles. Temozolomide is an alkylating agent that works by methylating DNA, targeting rapidly dividing tumor cells. The Stupp protocol is widely used as the standard comparator arm in clinical trials evaluating novel glioblastoma therapies.
- Other names
- Stupp regimentemozolomide + radiotherapy
02
Targets
DNA
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