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STX-015
- Development stage
- Discontinued
- Lead developer
- Sollis Therapeutics
- Modality
- Small Molecules
- Administration
- Epidural
01
Overview
STX-015 is an extended-release micropellet formulation of clonidine hydrochloride, a small molecule alpha-2 adrenergic receptor (ADRA2) agonist. Developed by Sollis Therapeutics, it is designed for delivery via a single epidural injection into the lumbar space to treat pain associated with lumbosacral radiculopathy (sciatica) and radicular pain. The mechanism involves reducing neuronal firing and pain signaling while providing anti-inflammatory effects at the site of nerve injury. It was intended as a non-opioid, non-steroid alternative for sciatica, but development was discontinued following the termination of Phase 3 clinical trials.
- Other names
- clonidine hydrochloride extended-release epidural micropelletclonidine micropelletclonidine HClclonidine hydrochloride
02
Targets
ADRA2A (α2A)IR (Imidazoline receptor)
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