stx140

STX140 is a synthetic steroidal compound belonging to the estrane steroid class. It is a bis-sulfamoylated derivative of 2-methoxyestradiol and acts as a multitargeted anticancer agent. Its primary mechanisms include potent inhibition of carbonic anhydrase II and steroid sulfatase (STS), as well as antiproliferative and antiangiogenic activities demonstrated in preclinical models. STX140 has shown significant tumor growth inhibition in xenograft models and exhibits activity across multiple cancer cell lines[1][5][7]. The compound was developed by researchers at the University of Bath in collaboration with Sterix Ltd[5].

Other names

(9beta,13alpha,14beta,17alpha)-2-methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate