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Drug intelligence / Profile preview
stx140
- Development stage
- Preclinical
- Lead developer
- Ipsen
- Modality
- Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intraperitoneal
01
Overview
STX140 is a synthetic steroidal compound belonging to the estrane steroid class. It is a bis-sulfamoylated derivative of 2-methoxyestradiol and acts as a multitargeted anticancer agent. Its primary mechanisms include potent inhibition of carbonic anhydrase II and steroid sulfatase (STS), as well as antiproliferative and antiangiogenic activities demonstrated in preclinical models. STX140 has shown significant tumor growth inhibition in xenograft models and exhibits activity across multiple cancer cell lines[1][5][7]. The compound was developed by researchers at the University of Bath in collaboration with Sterix Ltd[5].
- Other names
- (9beta,13alpha,14beta,17alpha)-2-methoxyestra-1,3,5(10)-triene-3,17-diyl disulfamate
02
Targets
CA2 (Carbonic Anhydrase 2)STS (Steroid sulfatase)TUBB (Tubulin (alpha and beta subunits))
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