SU-11652

SU-11652 is a potent small molecule inhibitor of multiple receptor tyrosine kinases (RTKs), including vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptors (FGFR), platelet-derived growth factor receptors (PDGFR), and the stem cell factor receptor Kit. It acts as a reversible and ATP-competitive inhibitor with anti-proliferative and pro-apoptotic properties in tumor cells. Preclinical studies have shown that it can induce apoptosis in cancer cell lines expressing mutant Kit and inhibit both SCF-dependent and independent phosphorylation of Kit. Additionally, it inhibits acid sphingomyelinase activity leading to lysosomal destabilization in cancer cells. It has also been identified as an inhibitor of nucleoside diphosphate kinase from Leishmania parasites[1][5][7][8][10].

Other names

5-[(Z)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamidePDGFR Tyrosine Kinase Inhibitor VIIIVEGFR Tyrosine Kinase Inhibitor XVIIVEGFR2 Kinase Inhibitor XIVVEGFR-2 Kinase Inhibitor XIVVEGFR 2 Kinase Inhibitor XIV