SU5402

SU5402 is a synthetic small molecule inhibitor of receptor tyrosine kinases, primarily targeting fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), and platelet-derived growth factor receptor beta (PDGFRβ). It acts by binding to the ATP-binding site of these kinases, thereby inhibiting their phosphorylation activity and downstream signaling. This compound has been widely used in research to study angiogenesis, developmental biology, and cancer pathways due to its ability to block FGF-, VEGF-, and PDGF-mediated cellular processes. SU5402 is not approved for clinical use but serves as an important experimental tool in molecular biology and pharmacology[1][7][8][9].

Other names

3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone