Drug intelligence / Profile preview

suaeda fruticosa ethanolic extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Suaeda fruticosa ethanolic extract is a botanical research compound derived from the halophytic medicinal plant *Suaeda fruticosa* (shrubby seablite), belonging to the family Amaranthaceae. The extract is characterized by a complex mixture of bioactive phytoconstituents, including phytol, thymol, n-hexadecanoic acid, farnesol, and 1-heptacosanol, alongside various phenolic compounds and flavonoids. Preclinical research in animal models has demonstrated that the extract possesses significant anti-inflammatory, antioxidant, and gastroprotective properties. Its mechanism of action involves the modulation of multiple inflammatory signaling pathways, specifically the down-regulation of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, and the inhibition of NF-κB and COX-2 expression. Additionally, it promotes the up-regulation of the anti-inflammatory cytokine IL-10 and enhances antioxidant defenses by increasing glutathione (GSH) levels. It is primarily investigated for its potential therapeutic application in ulcerative colitis, rheumatoid arthritis, and gastric ulcers.

Other names
Suaeda fruticosa extractethanolic extract of Suaeda fruticosa
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL10 (Interleukin-10)IL1B (Interleukin-1 beta)IL-6 (Interleukin 6)NF-κBTNFA (Tumor necrosis factor alpha (soluble))NOS2 (Nitric Oxide Synthase 2)

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