Drug intelligence / Profile preview

suanzaoren decoction + huanglian wendan decoction

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

Suanzaoren Decoction + Huanglian Wendan Decoction is a combination of two classic traditional Chinese medicine (TCM) herbal formulas. Suanzaoren Decoction (also known as Suan Zao Ren Tang or Sour Jujube Decoction) is composed of five herbs—Ziziphi Spinosae Semen (sour jujube seed), Poria, Chuanxiong Rhizoma, Anemarrhenae Rhizoma, and Glycyrrhizae Radix et Rhizoma—and has been used for centuries to treat insomnia and anxiety by nourishing the liver, calming the mind, and providing sedative effects[1][2][3][5][6]. Its mechanisms are thought to involve modulation of neurotransmitters such as GABA and serotonin, antioxidant activity, anti-inflammatory effects, neuroprotection, and regulation of monoamine neurotransmitters[6]. Huanglian Wendan Decoction is another TCM formula traditionally used for clearing heat-phlegm from the body; it contains herbs such as Coptidis Rhizoma (Huang Lian), Pinelliae Rhizoma Preparatum (Ban Xia), Bambusae Caulis in Taeniam (Zhu Ru), Aurantii Fructus Immaturus (Zhi Shi), Citri Reticulatae Pericarpium (Chen Pi), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (Zhi Gan Cao), Zingiberis Rhizoma Recens (Sheng Jiang), Jujubae Fructus (Da Zao). The combination is sometimes prescribed in TCM practice for complex cases involving both insomnia/anxiety with symptoms attributed to phlegm-heat disturbance. The precise mechanism of action for this specific combination has not been fully elucidated but likely involves synergistic sedative-hypnotic effects along with anti-inflammatory and neuroregulatory actions.

Other names
Suanzaoren Decoction and Huanglian Wendan DecoctionSZRD-HLWDD
02

Targets

GABRR (GABA-A receptor subunit rho)MAOA (Monoamine oxidase A)5-HT (Serotonin receptors)

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