substance p

Substance P is an endogenous undecapeptide tachykinin neuropeptide that has been administered experimentally as a **peptide biologic** rather than as an approved marketed drug. It primarily activates the **neurokinin 1 receptor**, with broader tachykinin biology reported at higher concentrations in some systems, and mediates neurogenic inflammation, vasodilation, nociceptive signaling, immune modulation, and smooth muscle or glandular secretory effects. In the provided sources, substance P appears in human challenge studies and early interventional development, including intradermal challenge work sponsored by GSK, a Phase I intra-arterial study in recent-onset type 1 diabetes sponsored by Vanilloid Genetics, and investigator-led studies exploring effects in headache, diabetes, dermatology, cardiovascular disease, and other translational settings. It is not an approved commercial medicine for any indication, but it is a real, publicly documented clinical and preclinical therapeutic or challenge agent.

Other names

substance pSPneurokinin Ptachykinin undecapeptide