Drug intelligence / Profile preview

succinylated gelatin + multiple electrolytes + sodium acetate

Development stage
Unknown
Lead developer
The First Affiliated Hospital of Guangzhou Medical University
Modality
Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
Administration
Intravenous
01

Overview

Succinylated gelatin + multiple electrolytes + sodium acetate is a physiologically balanced colloid solution used for fluid resuscitation and plasma volume expansion. It contains 4% succinylated gelatin (modified fluid gelatin) in a balanced electrolyte carrier that includes sodium, potassium, magnesium, and chloride, with sodium acetate acting as a metabolic buffer. Unlike older gelatin formulations based on 0.9% sodium chloride, this balanced version is designed to prevent hyperchloremic metabolic acidosis and maintain electrolyte homeostasis during the treatment of hypovolemia and shock. The gelatin component provides immediate intravascular volume expansion by increasing plasma oncotic pressure, while the electrolyte and acetate components support acid-base balance and physiological ion concentrations. The First Affiliated Hospital of Guangzhou Medical University has been involved in the clinical development and evaluation of this formulation for managing hypovolemic conditions.

Brand names
GeloPlasmaGeloas
Other names
Balanced succinylated gelatin injectionSuccinylated gelatin electrolyte injectionModified fluid gelatin balanced solution

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