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succinylcholine + saline
- Development stage
- Unknown
- Lead developer
- University of California, San Francisco
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Succinylcholine + saline is a drug combination used as a comparator arm in clinical trials conducted by the University of California, San Francisco, specifically for inducing neuromuscular blockade during electroconvulsive therapy (ECT). Succinylcholine is a depolarizing neuromuscular blocking agent that works by binding to nicotinic acetylcholine receptors at the neuromuscular junction, causing persistent depolarization and preventing further muscle contraction. In this specific trial context, saline is used as a placebo or diluent to match the volume of the reversal agent (sugammadex) used in the experimental arm, which reverses the effects of rocuronium.
- Other names
- suxamethonium + salinesuccinylcholine chloride + sodium chloride
02
Targets
Muscle-type nicotinic acetylcholine receptor
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