Drug intelligence / Profile preview

sucralfate + metronidazole + lidocaine

Development stage
Unknown
Lead developer
Gopal Lifesciences
Modality
Small Molecules
Administration
Topical, Rectal
01

Overview

Proctocalm is a topical combination cream containing sucralfate, metronidazole, and lidocaine (lignocaine) hydrochloride, developed and manufactured by Gopal Lifesciences. It is indicated for the local treatment and symptomatic relief of painful anorectal conditions, including anal fissures, hemorrhoids (piles), fistulas, and post-operative anorectal wounds. Within the formulation, lidocaine acts as a local anesthetic to provide rapid pain relief by blocking voltage-gated sodium channels. Metronidazole serves as an antibacterial agent targeting anaerobic bacteria to prevent local infections and reduce inflammation. Sucralfate acts as a cytoprotective agent, forming a physical barrier over damaged mucosal tissue to shield it from irritation and promote wound healing.

Brand names
Proctocalm
Other names
sucralfate + metronidazole + lidocaine hydrochloridesucralfate + metronidazole + lignocainesucralfate + metronidazole + lignocaine hydrochloride
02

Targets

NeuraminidaseFGF2MUC2 (Mucin-2)PEP (Pepsin)DNANaV (Voltage-gated sodium channels)

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