Drug intelligence / Profile preview

sucrose + hesperetin

Development stage
Unknown
Modality
Drug Delivery Systems
Administration
Oral
01

Overview

The combination of sucrose and hesperetin is being studied as an intervention for blood glucose regulation and energy metabolism. Hesperetin is a flavonoid found in citrus fruits with potential antioxidant, anti-inflammatory, and antidiabetic properties. When combined with sucrose, it appears to influence blood glucose regulation and energy metabolism. A clinical cross-over intervention study is investigating the effects of hesperetin (50 mg/L) combined with 7% sucrose compared to control solutions (an equally sweet 10% sucrose solution and an isocaloric 7% sucrose solution) on markers of energy metabolism, time-dependent blood glucose fluctuations, energy intake, appetite scores, and metabolic/hormonal responses in metabolically healthy volunteers. Research also suggests that hesperetin can enhance the sweet taste of substances, potentially allowing for reduced sugar content.

02

Targets

PTPN1 (Protein tyrosine phosphatase 1B)

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