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Suez Canal Univ. VEGFR-2 compound 15
- Development stage
- Preclinical
- Lead developer
- Suez Canal University
01
Overview
Suez Canal Univ. VEGFR-2 compound 15: sourced facts only. name: "Comparing compounds 15 and 18 to sorafenib, the in vitro VEGFR-2 inhibitory activity displayed encouraging selective efficacy with IC50 values of 13, 67, and 30 nM, respectively." [PMID:37002183]; target: "Comparing compounds 15 and 18 to sorafenib, the in vitro VEGFR-2 inhibitory activity displayed encouraging selective efficacy with IC50 values of 13, 67, and 30 nM, respectively." [PMID:37002183]; developer: "Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt." [PMID:37002183]; stage: "Compound 15 caused apoptotic breast cancer cell death with 55.11-fold cell-cycle arrest at the S-phase, where it affected the apoptosis-mediated genes through upregulating P53, Bax, caspases 3, 8, and 9 and downregulating the antiapoptotic gene Bcl-2." [PMID:37002183]
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)
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