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Suhexiang Pill is a traditional Chinese medicine (TCM) formula with a history dating back to the Tang Dynasty. It is composed of multiple herbal and animal-derived ingredients—typically 15 in classical formulations—including principal components such as Styrax (Su He Xiang), Musk (She Xiang), Borneol (Bing Pian), and Benzoin (An Xi Xiang)[8]. The formula is categorized among TCM prescriptions that "warm and open sensory orifices" and is traditionally used for conditions involving loss of consciousness due to stroke, seizures, or severe infections ("plague"), as well as for acute cardiovascular events[8][3]. Modern research has explored its use in acute ischemic stroke[7][2][9] and severe COVID-19[3], where it may act by modulating inflammatory pathways such as interleukin 6/10 signaling, TNF signaling, Janus kinase/STAT3 pathway, PI3K-Akt pathway, T cell receptor signaling, Toll-like receptor pathway, chemokine signaling and others. Its mechanism involves synergistic regulation of immune response and suppression of cytokine storms[3]. The bioactive compounds target multiple genes/proteins involved in inflammation and vascular function.
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