sul-121

SUL-121 is a novel small molecule compound with demonstrated anti-inflammatory, bronchodilating, and anti-oxidative properties in experimental models, developed as part of the SUL-compounds series, originally inspired by the protective effects of natural hibernation mechanisms[1][2]. It has shown therapeutic potential in diseases characterized by oxidative stress and inflammation, including Chronic Obstructive Pulmonary Disease (COPD) and diabetic kidney injury[1][2][4]. In preclinical studies, SUL-121 inhibited airway inflammation and hyperresponsiveness (AHR) in models of COPD, largely by reducing oxidative stress and preventing the release of pro-inflammatory cytokines such as IL-8[2][7]. It also preserved endothelial function and attenuated oxidative damage in diabetic nephropathy models[4]. SUL-121 does not affect basal airway tone or metabolic parameters in healthy animals[2][4]. As of current knowledge, SUL-121 is not approved for clinical use and remains in preclinical development[1][11].

Other names

SUL-121SUL121SUL 121Sul-121 hydrochlorideSul121 hydrochlorideSul 121 hydrochlorideSUL-121 HClSUL121 HClSUL 121 HCl