Drug intelligence / Profile preview

sulfacetamide + prednisolone

Development stage
Approved
Lead developer
Bausch + Lomb
Modality
Small Molecules
Administration
Ophthalmic, Topical
01

Overview

Sulfacetamide + prednisolone is a combination ophthalmic medication containing two active ingredients: sulfacetamide, a sulfa antibiotic, and prednisolone, a corticosteroid. Sulfacetamide inhibits bacterial growth by interfering with folic acid synthesis in susceptible bacteria, providing bacteriostatic action against organisms such as Escherichia coli, Staphylococcus aureus, Streptococcus (viridans group), Haemophilus influenzae, Klebsiella species, and Enterobacter species. Prednisolone acts as an anti-inflammatory agent by suppressing the immune response to reduce swelling, redness, itching, and pain in the eye. This combination is primarily used to treat inflammatory ocular conditions where there is either an existing bacterial infection or risk of one—such as conjunctivitis or chronic anterior uveitis—and for preventing damage from chemicals or foreign objects in the eye. The product is available as an ophthalmic solution or ointment for topical use only[1][2][3][4][5][7].

Brand names
BlephamideIsopto CetapredMetimydPredamidePredsulfairSulphrinSulsterVasocidinOptimydBlephamide S.O.P.CetapredOcu-Lone C
Other names
sulfacetamide sodium and prednisolone sodium phosphate ophthalmic solution
02

Targets

GR (Glucocorticoid receptor)DHPS (Dihydropteroate synthase)

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