sulfadiazine + trimethoprim

Sulfadiazine + trimethoprim is a combination of two antibiotics used primarily in veterinary medicine to treat bacterial infections in animals, especially horses. The combination acts synergistically by inhibiting sequential steps in the bacterial folic acid synthesis pathway: sulfadiazine inhibits dihydropteroate synthase, while trimethoprim inhibits dihydrofolate reductase. This dual inhibition results in a bactericidal effect against susceptible bacteria. It is indicated for the treatment of respiratory tract infections (including pneumonia), urinary tract infections, gastrointestinal infections, wound and uterine infections, abscesses, strangles (in horses), equine protozoal myeloencephalitis (EPM), and other conditions caused by susceptible microorganisms[2][3][9]. The drug is available as oral suspensions, boluses/tablets/paste/injection for animal use.

Brand names

Equisul-SDTTribrissenTucoprimDi-Trim 24%Di-Trim 400 PasteDi-Trim400 PasteDi-Trim-400 PasteDi-Trim 48% InjectionTribrissen 120 TabletsTribrissen120 TabletsTribrissen-120 TabletsTribrissen 30 TabletsTribrissen30 TabletsTribrissen-30 TabletsTribrissen 480 TabletsTribrissen480 TabletsTribrissen-480 TabletsTribrissen 960 TabletsTribrissen960 TabletsTribrissen-960 TabletsTribrissen 400 Oral PasteTribrissen400 Oral PasteTribrissen-400 Oral PasteTribrissen 48% InjectionTribrissen 60 Oral SuspensionTribrissen60 Oral SuspensionTribrissen-60 Oral SuspensionTucoprim PowderUniprim Powder

Other names

Sulfadiazine; TrimethoprimSulfadiazine / TrimethoprimSulfadiazine, TrimethoprimSulfadiazine/TrimethoprimSULFADIAZINE and TRIMETHOPRIMTrimethoprim / SulfadiazineTrimethoprim and SulfadiazineTrimethoprim;Sulfadiazine