sulfadiazine sodium

Sodium sulfadiazine is the sodium salt form of sulfadiazine, a short-acting sulfonamide antibiotic. It functions as a competitive antagonist of para-aminobenzoic acid (PABA), thereby inhibiting the bacterial enzyme dihydropteroate synthase, which is essential for the synthesis of dihydrofolic acid. This inhibition disrupts the production of folic acid, a necessary precursor for bacterial DNA and RNA synthesis, leading to a bacteriostatic effect. It is primarily indicated for the treatment of infections caused by susceptible strains of organisms, including urinary tract infections, chancroid, and nocardiosis, and is used as prophylaxis for rheumatic fever and meningococcal meningitis. In pharmaceutical manufacturing, it is often produced as an injectable generic product for parenteral administration.

Other names

sodium sulfadiazinesulfadiazine sodium salt