sulfamethoxypyridazine

Sulfamethoxypyridazine is a sulfonamide antibacterial agent and small molecule antibiotic. It acts as a competitive inhibitor of the bacterial enzyme dihydropteroate synthase, thereby blocking folic acid synthesis essential for bacterial DNA and RNA production[1][2][3][4][6][7]. This mechanism makes it effective against a broad spectrum of Gram-negative bacteria and other microorganisms. Sulfamethoxypyridazine is used to treat various infections, including urinary tract infections, gonorrhea, bronchitis, inflammation, vaginal irritation, severe acute thrush, dermatitis herpetiformis (as an alternative to dapsone), meningococcal meningitis (in combination therapy), acute otitis media in children, trachoma (including inclusion conjunctivitis), nocardiosis, chancroid caused by Haemophilus ducreyi, toxoplasmosis (with pyrimethamine), and malaria due to chloroquine-resistant Plasmodium falciparum[1][2][5][6]. It has also shown efficacy in animal models for Pneumocystis carinii pneumonia[5]. The drug is well absorbed orally with moderate protein binding and primarily excreted unchanged in urine. Common side effects include gastrointestinal disturbances and allergic reactions; rare but serious adverse events such as Stevens-Johnson syndrome or hepatotoxicity may occur[6].

Brand names

SulmetinLederkynMidicelDavosinKynex

Other names

SMPR